The persistence of healthcare-acquired infections (HAI) in U.S. hospitals has resulted in thousands of annual deaths. In addition, the rise of antibiotic-resistant bacteria and the noncompliance of healthcare workers and patients with proper hygienic protocols has created a need for new cost-effective antimicrobial agents. Silver is well-known for its excellent antimicrobial properties, but its high cost limits its applications. We investigate the synthesis of silica-silver complex core-shell particles as a means of vastly decreasing the amount of silver needed. The synthesized antimicrobial agent is then impregnated into a fabric to serve as an antimicrobial coating. The structure of the novel antimicrobial agent is characterized using NMR, IR, TEM, and UV-vis spectroscopy. Agar plate tests and washing tests are conducted to determine the short-term and long-term antimicrobial efficacy of the silver complex-silica agent and to optimize its antimicrobial properties.

A novel cost-effective antimicrobial

compound: Silver-Silica complex

AdvisorsYanika Schneider, Dr. Folarin Erogbogbo

Authors: Neda Nasr, Thuy O, Cynthia Ouandji, Mrudula Vemuri