According to the International Osteoporosis Foundation, nine milion osteoporosis-related fractures occur annually. When treating fractures in osteoporotic bone with plate and screws, decreased bone purchase and increased risk of microfractures due to the weakened structure of the bone can lead to screw loosening and ultimately implant failure. The basis of this project revolves around the development of a PMMA-based bone plate which could achieve fixation and stabilization of the bone without the use of screws. Preliminary validation of osteoporotic-like state induced by EDTA treatment of bone samples demonstrated that immersion in 0.5M EDTA for 12 days is capable of reducing the weight of treated samples. The EDTA treatment method and capability of PMMA to improve plate fixation will be validated with cross sectioning and screw pull-out strength testing on control and EDTA-treated bone samples. Following the validation of our methods, compression, three point flexural, and pull-out plate prototype. From the results of testing, an analysis of the PMMA-based plate fixation method and comparison to the plate and screw fixation method will be made.

Less Aggressive Adhesive-based Osteoporotic

Implant for Simple Long Bone Fractures

Advisor: Dr. Guna Selvaduray

Authors: George Karoglou, Keng-Tsai Lin,

Pedram Samimi, Kojiro Wada