There are currently 29.1 million diabetics in the United States, of which roughly 40% must take some form of insulin administered by subcutaneous injection. An Insulin patch will be designed here will combine three common transdermal diffusion techniques; chemical penetration enhancers (CPE), a microneedle array, and iontophoresis in an effort to open the lattice structure of the epidermis, allowing the diffusion of insulin molecules into the bloodstream. This study will identify the ideal CPE at optimal concentration for penetrating through the epidermis for effective delivery of insulin, and if a microneedle array and iontophoresis is needed. This study provides the basis for designing a transdermal insulin delivery device that will be cost effective and more user friendly than subcutaneous injections. Further research is needed to understand dosage delivery and to identify the best type of microneedles to use as well as options for reservoir design.
Transdermal Insulin Patch
Advisor: Brooke Lustig
Authors: Leo Chestang, Mirwais Razawi