Transcatheter Aortic Valve Replacement (TAVR) is a minimally invasive procedure that replaces a stenotic aortic valve with a bioprosthetic transcatheter heart valve (THV). Paravalvular Leakage (PVL) often occurs between the stent frame of the THV and the surrounding aortic root, and is one of the leading causes of post-TAVR mortality. The objective of this project is to reduce PVL in TAVR patients through the design and implementation of a universal sealant into current THVs such as the Edwards SAPIEN XT and Medtronic CoreValve. We designed and prototyped a hydrogel-filled ePTFE sealant to be tested for leakage under physiological hydrostatic pressure conditions. Comparison with a non-sealed control will demonstrate the effectiveness of our novel approach. If successful, our univerSEAL will help to improve and standardize the performance of current THVs, lowering overall healthcare costs of the TAVR procedure and reducing the occurrence of reoperations.

univerSEAL: a Universal Approach to Reduce Paravalvular Leakage in Transcatheter Aortic Valve Replacement

Advisor: Dr. Alessandro Bellofiore

Authors: Travis Carmichael, Sylvia Shacker, Jennifer Vu