Aortic stenosis is the narrowing of valve leaflets due to calcium buildup, restricting the blood flow in the heart. Surgical Aortic Valve Replacement (SAVR) is a current treatment, which poses high risks for elderly patients with pre-existing morbid conditions. Therefore, a minimally invasive procedure called Transcatheter Aortic Valve Replacement (TAVR) can be performed, replacing the faulty valve with a bioprosthetic valve, but it poses post-procedure risk of paravalvular leakages (PVL). There is a need to reduce PVL to increase mortality rates of patients post TAVR procedure. A proposed solution is to design an interchangeable sealant that will be suitable to all types of THVs. The design is a hollow O-ring shape made of two different materials, polyethylene terephthalate, and expanded polytetrafluorethylene. Efficiency will be tested on two sizes of Edwards Sapien (23 mm, 26 mm) under systolic hydrostatic pressures,normal, mild and severe, with desired results of <12% PVL rate.
Advisor: Dr. Alessandro Bellofiore
Authors: Jenny Man, Jesan Kristine Suasin, Sepideh Yazdi