Diabetes is the 7th leading cause of death in the United States, and roughly 1.3 million people have type 1 diabetes in the world. It is treated using insulin syringes. Although syringes can never be replaced, this research could potentially lead to an alternative method for drug delivery. This noninvasive, transdermal insulin nanoparticle patch transports insulin across the skin barrier, eliminating pain and reducing cost to the user. Insulin encapsulated nanoparticles have been synthesized in the lab and have been characterized using UV spectroscopy, which was used to determine insulin encapsulation efficiency in the nanoparticles; dynamic light scattering, to determine size distribution as well as morphology; and a Franz diffusion cell to determine relative diffusion across porcine skin. Implications include diffusion rate and potential generation of harmful byproducts.
Transdermal Insulin Nanoparticle Patch
Advisor: Dr. Folarin Erogbogbo
Authors: Ricky Dhanota, Jasiah Sta Maria, Amna Rana