Cement Augmentation for Osteoporotic Bones

Authors: Justin Do, Wendy Ho, Ngoc Le

Advisor: Dr. Guna Selvaduray

Osteoporosis is an irreversible degenerative bone disease characterized by loss of bone tissue and enlargement of spaces between bony struts. The thinning and weakening of the bones cause pain, limitation in daily activities, and fractures. The primary treatment of the disease is surgically providing a stable immobilization of the afflicted bones. However, the poor bone stock in osteoporosis remarkably hinders the stable fixation, and there are currently no effective measures to increase bone mass in osteoporosis. Recent research has demonstrated that bone cement injection is a feasible and effective method for reinforcing bone mass. This project focuses on creating osteoporotic bones and investigating the effect of PMMA injection on the mechanical strength of osteoporotic femurs. We have obtained an osteoporotic model by demineralizing pig femur with Ethylenediaminetetraacetic acid (EDTA). The treated bones displayed a reduction in bone mass from 21% to 26% and exhibited elastic deformation under compression. The remaining steps of the project will address if the porosity characteristics of our osteoporotic model are similar to realistic osteoporotic bones, and whether there is a relationship between the PMMA injection and the mechanical strength of osteoporotic bones. The augmentation effect of PMMA could prevent fractures due to osteoporosis and enhance treatment of an osteoporotic fracture.