Background: Osteoporosis is a disease which affects many people. It is mainly caused by genetic predisposition, smoking, lack of physical mobility, and old age. Reparation of an osteoporotic fracture, typically involves the fixation of a fracture plate to provide stability for the bone’s natural healing process. A standard method to consistently replicate osteoporotic tissue will provide insight to the differences between osteoporotic and “healthy” bones. Methods: Femoral samples will be cleaned and sterilized prior to demineralization with Ethylenediaminetetraacetic Acid (EDTA). Metallographic techniques along with volume displacement will aide in the characterization of pore-size distribution, with pull-out strength profiling the bone's integrity pre/post-demineralization. Goals: This research aims to generate a method which will reliably induce osteoporosis for the assessment of augmented fixation methods in treating osteoporotic femur fractures.
Generating an Osteoporotic Model in Pig Femurs through Demineralization with EDTA
Advisor: Dr. Guna Selvaduray
Authors: Hanna Ali, Chandler Robak, Hernan Benitez