In the 21st century, there is a tremendous demand to develop advanced surgical procedures. Currently, most of the commercialized biodegradable skin staples are made of 50:50 synthetic poly(lactic-co-glycolic acid) (PLGA) copolymers, using rectangular-shaped staples. However, numerous reports have shown that it cannot be applied on the skin accurately, with the potential of causing a wider separation of the epithelial surface. To overcome this deficiency, M-shaped, U-shaped, C-shaped staples were designed, to maximize the stability of the staples after implantation, and to improve the applicability and degradation duration. Samples will be fabricated using a solvent-casting technique and subjected to degradation studies in a phosphate-buffered saline (PBS) solution at 37°C. This study will serve as a starting point for future studies in bio-absorbability technology, and resolve some of the issues that currently face wound closure techniques.

In Vitro Degradation Study of the Biodegradable PLGA Copolymers Skin Staples with Different Shapes

Advisor: Dr. Guna Selvaduray

Authors: Ka Lok Chan, Daijia Zhang