Abstract: International Business Machining (IBM) Initiative

Creation of an intestinal stoma is a common bowel surgical procedure, in which the exteriorization of the small bowel or large bowel through the anterior abdominal wall is performed. Intestinal stomas play an important role in the management of gastrointestinal diseases for over 500,000 individuals within the US currently, and with approximately 120,000 new stomas created annually 1,2. Prolapse, or intussusception of the bowel through the abdominal opening, is a distressing complication with associated risks including stoma obstruction, bowel edema, bowel perforation, and high intra-abdominal pressure 3. Hypotheses for mitigating the risks of recurring stoma prolapse is the development of an anti-prolapse device. However, material characterization studies used by FDA to determine the safety and efficacy of medical device materials is expensive. Here we show that leveraging tools from the International Business Machining (IBM) Academic Initiative can assist in chemical characterization of medical device materials for FDA biosafety protocols. We utilized IBM partnership technology including IBM Cloud, Data Science, IBM Engineering and IBM Watson to analyze small-molecule surface chemistry. Our results demonstrate that IBM tools can be used to make characterization inferences between data sets compiled from multiple biocompatible studies. We anticipate that this project will contribute to alternative avenues of data analytics for the approval of medical devices by the FDA.